Improved framework for tractography reconstruction of the Optic Radiation

The optic radiation (OR) is one of the major components of the visual system and a key structure at risk in white matter diseases such as multiple sclerosis (MS). However, it is challenging to perform track reconstruction of the OR using diffusion MRI due to a sharp change of direction in the Meyer’s loop and the presence of kissing and crossing fibers along the pathway.

Major contributions

✔ We provide an automatic tool to obtain the optic radiation reconstruction including the anterior loop through tractography technique.

✔ This pipeline requires a 3D-structural image and a DWI sequence (single-shell sequence using 60 or more diffusion-encoding gradient directions). It is highly recommended to include a gradient field map sequence.

✔ We present a novel framework based on clustering techniques and anatomical knowledge of optic radiation tract.

✔ The pipeline output directory contains the optic radiation file (format .tck) and the seed and target masks (thalamus and visual cortex).

Co-authors

Eloy Martínez de las Heras

PhD candidate.

Federico Varriano

MSc.

Vesna Prčkovska

PhD.

Carlos Laredo

PhD candidate.

Magí Andorrà

PhD candidate.

Elena H.Martínez-Lapiscina

MD, PhD.

Anna Calvo

MSc.

Erika Lampert

MSc.

Pablo Villoslada

MD, PhD.

Albert Saiz

MD, PhD.

Alberto Prats Galino

MD, PhD.

Sara Llufriu

MD, PhD.

Contact us

  • unitatem.hcb@gmail.com
  • +34 93 2275400 ext. 5414
  • Hospital Clínic Barcelona. Calle Villarroel 170, scale 6, floor 4
    Zip code 08036. Barcelona, Spain