Curriculum Vitae

Profile Picture

Personal Data

Name:
Eloy Martínez de las Heras
Birthdate:
May/31/1982
Professional Address:
Neuroimmunology and Multiple Sclerosis Unit, Clinical and experimental neuroscience area. Advanced Imaging in Neuroimmunological Diseases (ImaginEM). Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) – Hospital Clinic of Barcelona (HCB). Phone: 0034 932275414; Fax: 0034 932275783. 170 Villarroel St. Zip 08036. Barcelona. Spain.
Email:
EMARTIND@recerca.clinic.cat
Identifiers:
Clinic Barcelona | ORCID | ResearchGate

University Education

  • Chemical Engineering - Universitat Rovira I Virgili, Tarragona (Spain), July 2007
  • Master’s in Biomedical Engineering - University of Barcelona & Polytechnic University of Catalonia (Spain). 2007-2009. 120 ECTS.
    Topic: Development and calibration of the portable gamma camera in SPECT imaging with parallel collimator.
  • PhD in Medicine and Translational research - University of Barcelona, Barcelona (Spain). 2014-2017.
    Title: Development of an improved framework for tractography reconstruction of white matter fibers based on diffusion-weighted magnetic resonance imaging and its implementation in the study of structural connectivity in patients with multiple sclerosis.
    Supervisors: Sara Llufriu Duran and Alberto Prats Galino. CUM LAUDE.
  • Postgraduate in Data Science and Big data - University of Barcelona, Barcelona (Spain). July 2021.

Work Experience

  • 02/2018 – present: Collaborator & Course instructor at Master in data science, Universitat Oberta de Catalunya (UOC).
  • 07/2017 – present: Postdoctoral researcher (R2A) in Medical Imaging Processing of the Advanced Imaging in Neuroimmunological Diseases research group at Hospital Clinic Barcelona and IDIBAPS. Supervisor: Sara Llufriu Duran.
  • 07/2010-06/2017: Predoctoral researcher & Neuroimaging engineer at Neuroimmunology-Multiple Sclerosis Unit, Hospital Clinic of Barcelona, Spain.
  • 07/2009-07/2010: Research fellow in neuroimage analysis at Fetal and Perinatal research group, Fundació Clínic Barcelona, Spain.

General Quality Indicators of Scientific Production

Total Publications (Pubmed):
42
Total Citations (WoS Core):
1431
h-index (WoS Core):
17

Short Summary of the CV

I am Eloy Martínez de las Heras, a postdoctoral researcher in biomedical engineering. For over a decade, I have worked with the Neuroimmunological Diseases group at the Hospital Clinic of Barcelona, specifically with ImaginEM, led by Dr. Sara Llufriu. My expertise lies in MRI data processing, and I have actively contributed to the creation and validation of innovative algorithms in this field. Some examples of these methods include whole-brain parcellation techniques, atrophy measurements of the brain and spinal cord, brain network analysis, and lesion characterization. Throughout my career, I have participated in the publication of more than 40 original articles in prominent clinical and technical journals. These works cover a range of MR techniques, including diffusion-weighted imaging, spectroscopy, spinal cord imaging, and synthetic MRI. Of these articles, I have written eight as the primary author. Currently, I am responsible for implementing an automated processing workflow within the Extensible Neuroimaging Archive Toolkit (XNAT) platform. This workflow allows for the extraction of advanced quantitative MRI measures to aid in disease diagnosis, treatment response, and follow-up.

Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes.
Martinez-Heras E, Solana E, Vivó F, et al.
J Neurol Neurosurg Psychiatry. 2023 Jun 15:jnnp-2023-331531.
http://doi.org/10.1136/jnnp-2023-331531
Diffusion tensor imaging metrics associated with future disability in multiple sclerosis.
Martinez-Heras, E & Lopez-Soley, E. & Solana, E, et al.
Sci Rep 13, 3565 (2023).
https://doi.org/10.1038/s41598-023-30502-5
Using The Virtual Brain to study the relationship between structural and functional connectivity in patients with multiple sclerosis: a multicenter study.
Martí-Juan G, Sastre-Garriga J, Martinez-Heras E, et al.
Cereb Cortex. 2023 Feb 22:bhad041.
doi: 10.1093/cercor/bhad041
Removing the effects of the site in brain imaging machine-learning - Measurement and extendable benchmark.
Solanes A, Gosling CJ, Fortea L, et al.
Neuroimage. 2023 Jan;265:119800.
doi: 10.1016/j.neuroimage.2022.119800
Intense long-term training impairs brain health compared with moderate exercise: Experimental evidence and mechanisms.
Sangüesa G, Batlle M, Muñoz-Moreno E, et al.
Ann N Y Acad Sci. 2022 Dec;1518(1):282-298.
doi: 10.1111/nyas.14912
Applying multilayer analysis to morphological, structural and functional brain networks to identify relevant dysfunction patterns.
Martinez-Heras E & Casas-Roma J, Solé-Ribalta A, et al.
Network Neuroscience 2022.
doi: 10.1162/netn_a_00258
Recent advances in the longitudinal segmentation of multiple sclerosis lesions on magnetic resonance imaging: a review.
Diaz-Hurtado M, Martínez-Heras E, Solana E, et al.
Neuroradiology. 2022 Jul 22.
doi: 10.1007/s00234-022-03019-3
Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis.
Lopez-Soley E, Martinez-Heras E, Andorra M, et al.
J Pers Med. 2021 Oct 28;11(11):1107.
doi: 10.3390/jpm11111107
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers.
Cohen-Adad J, Alonso-Ortiz E, Abramovic M, et al.
Sci Data. 2021 Sep 23;8(1):251.
doi: 10.1038/s41597-021-01044-0
Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences.
Reid LB, Martinez-Heras E, Manjón JV, et al.
Hum Brain Mapp. 2021 Dec 15;42(18):5911-5926.
doi: 10.1002/hbm.25658
Diffusion-Weighted Imaging: Recent Advances and Applications.
Martinez-Heras E & Grussu F, Prados F, et al.
Semin Ultrasound CT MR. 2021 Oct;42(5):490-506.
doi: 10.1053/j.sult.2021.07.006
Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients.
Martinez-Heras E & Solana E, Montal V, Vilaplana E, et al.
Sci Rep. 2021 Aug 19;11(1):16805.
doi: 10.1038/s41598-021-96132-x
Generic acquisition protocol for quantitative MRI of the spinal cord.
Cohen-Adad J, Alonso-Ortiz E, Abramovic M, et al.
Nat Protoc. 2021 Oct;16(10):4611-4632.
doi: 10.1038/s41596-021-00588-0
Lesion probability mapping in MS patients using a regression network on MR fingerprinting.
Hermann I, Golla AK, Martínez-Heras E, et al.
BMC Med Imaging. 2021 Jul 8;21(1):107.
doi: 10.1186/s12880-021-00636-x
Synthetic MRI in subarachnoid haemorrhage.
Montejo C, Laredo C, Llull L, et al.
Clin Radiol. 2021 Oct;76(10):785.e17-785.e23.
doi: 10.1016/j.crad.2021.05.021
Cortical fractal dimension predicts disability worsening in Multiple Sclerosis patients.
Roura E, Maclair G, Andorrà M, et al.
Neuroimage Clin. 2021;30:102653.
doi: 10.1016/j.nicl.2021.102653
Accelerated white matter lesion analysis based on simultaneous T1 and T2∗ quantification using magnetic resonance fingerprinting and deep learning.
Hermann I, Martínez-Heras E, Rieger B, et al.
Magn Reson Med. 2021 Jul;86(1):471-486.
doi: 10.1002/mrm.28688
Incidence and Impact of COVID-19 in MS: A Survey From a Barcelona MS Unit.
Sepúlveda M, Llufriu S, Martínez-Hernández E, et al.
Neurol Neuroimmunol Neuroinflamm. 2021 Jan 27;8(2):e954.
doi: 10.1212/NXI.0000000000000954
Oligoclonal IgM bands in the cerebrospinal fluid of patients with relapsing MS to inform long-term MS disability.
Capuano R, Zubizarreta I, Alba-Arbalat S, et al.
Mult Scler. 2021 Oct;27(11):1706-1716.
doi: 10.1177/1352458520981910
Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis.
Lopez-Soley E, Solana E, Martínez-Heras E, et al.
Front Neurol. 2020 Oct 30;11:581700.
doi: 10.3389/fneur.2020.581700
Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI.
Martínez-Heras E & Solana E, Prados F, Andorrà M, et al.
Neuroimage Clin. 2020;28:102411.
doi: 10.1016/j.nicl.2020.102411
Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years.
Pulido-Valdeolivas I, Andorrà M, Gómez-Andrés D, et al.
Sci Rep. 2020 Aug 7;10(1):13333.
doi: 10.1038/s41598-020-70255-z
Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA.
Radua J, Vieta E, Shinohara R, et al.
Neuroimage. 2020 Sep;218:116956.
doi: 10.1016/j.neuroimage.2020.116956
Modified connectivity of vulnerable brain nodes in multiple sclerosis, their impact on cognition and their discriminative value.
Martinez-Heras E & Solana E, Casas-Roma J, Calvet L, et al.
Sci Rep. 2019 Dec 27;9(1):20172.
doi: 10.1038/s41598-019-56806-z
Spanish validation of the telephone assessed Expanded Disability Status Scale and Patient Determined Disease Steps in people with multiple sclerosis.
Solà-Valls N, Vicente-Pascual M, Blanco Y, et al.
Mult Scler Relat Disord. 2019 Jan;27:333-339.
doi: 10.1016/j.msard.2018.11.018
Magnetic resonance markers of tissue damage related to connectivity disruption in multiple sclerosis.
Martinez-Heras E & Solana E, Martinez-Lapiscina EH, Sepulveda M, et al.
Neuroimage Clin. 2018 Jul 12;20:161-168.
doi: 10.1016/j.nicl.2018.07.012
Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.
Armangue T, Spatola M, Vlagea A, et al.
Lancet Neurol. 2018 Sep;17(9):760-772.
doi: 10.1016/S1474-4422(18)30244-8
Assessing Biological and Methodological Aspects of Brain Volume Loss in Multiple Sclerosis.
Andorra M, Nakamura K, Lampert EJ, et al.
JAMA Neurol. 2018 Oct 1;75(10):1246-1255.
doi: 10.1001/jamaneurol.2018.1596
Time efficient whole-brain coverage with MR Fingerprinting using slice-interleaved echo-planar-imaging.
Rieger B, Akçakaya M, Pariente JC, et al.
Sci Rep. 2018 Apr 27;8(1):6667.
doi: 10.1038/s41598-018-24920-z
Cortical microstructural changes along the Alzheimer's disease continuum.
Montal V, Vilaplana E, Alcolea D, et al.
Alzheimers Dement. 2018 Mar;14(3):340-351.
doi: 10.1016/j.jalz.2017.09.013. Epub 2017 Oct 31. PMID: 29080407.
Structural networks involved in attention and executive functions in multiple sclerosis.
Martinez-Heras E & Llufriu S, Solana E, Sola-Valls N, et al.
Neuroimage Clin. 2016 Dec 5;13:288-296.
doi: 10.1016/j.nicl.2016.11.026.
Enhanced mirror activity in 'crossed' reaction time tasks in multiple sclerosis.
Cabib C, Llufriu S, Martinez-Heras E, et al.
Clin Neurophysiol. 2016 Apr;127(4):2001-9.
doi: 10.1016/j.clinph.2016.01.017.
Reproducibility of the Structural Connectome Reconstruction across Diffusion Methods.
Prčkovska V, Rodrigues P, Puigdellivol Sanchez A, et al.
J Neuroimaging. 2016 Jan-Feb;26(1):46-57.
doi: 10.1111/jon.12298.
Improved Framework for Tractography Reconstruction of the Optic Radiation.
Martínez-Heras E, Varriano F, Prčkovska V, et al.
PLoS One. 2015 Sep 16;10(9):e0137064.
doi: 10.1371/journal.pone.0137064.
The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS.
Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, et al.
BMC Res Notes. 2014 Dec 15;7:910.
doi: 10.1186/1756-0500-7-910.
Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis.
Llufriu S, Sepúlveda M, Blanco Y, et al.
PLoS One. 2014 Dec 1;9(12):e113936.
doi: 10.1371/journal.pone.0113936.
Abnormal control of orbicularis oculi reflex excitability in multiple sclerosis.
Cabib C, Llufriu S, Martínez-Heras E, et al.
PLoS One. 2014 Aug 1;9(8):e103897.
doi: 10.1371/journal.pone.0103897.
Colour vision impairment is associated with disease severity in multiple sclerosis.
Martínez-Lapiscina EH, Ortiz-Pérez S, Fraga-Pumar E, et al.
Mult Scler. 2014 Aug;20(9):1207-16.
doi: 10.1177/1352458513517591.
Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis.
Gabilondo I, Martínez-Lapiscina EH, Martínez-Heras E, et al.
Ann Neurol. 2014 Jan;75(1):98-107.
doi: 10.1002/ana.24030.
Cognitive functions in multiple sclerosis: impact of gray matter integrity.
Llufriu S, Martínez-Heras E, Fortea J, et al.
Mult Scler. 2014 Apr;20(4):424-32.
doi: 10.1177/1352458513503722.
Retinal periphlebitis is associated with multiple sclerosis severity.
Ortiz-Pérez S, Martínez-Lapiscina EH, Gabilondo I, et al.
Neurology. 2013 Sep 3;81(10):877-81.
doi: 10.1212/WNL.0b013e3182a3525e.
Influence of corpus callosum damage on cognition and physical disability in multiple sclerosis: a multimodal study.
Llufriu S, Blanco Y, Martinez-Heras E, et al.
PLoS One. 2012;7(5):e37167.
doi: 10.1371/journal.pone.0037167.

R&D Projects

Project Code Project Name Agency/Fund Duration Role
2021-SGR-01325 Grup d'Imatge Avançada en Malalties Neuroimmunològiques (ImaginEM) Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) 01/01/2022-31/12/2024 Team member
PI21/01189 Neuroimaging multi-modal approach to understand mechanisms of tissue DAmage in Multiple sclerosis patients and predictive models (daMoS) Instituto Carlos III (Ministerio de ciencia e Innovacion).
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute), Barcelona, Spain)		 01/01/2022-31/12/2024 Team member
TV3_Ictus_17 Blood brain barrier disruption after subarachnoid hemorrhage: clinical relevance, role of hyperglycemia and effect of potentiating endogenous antioxidant mechanisms. A translational study. Fundació La Marató de TV3.
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute), Barcelona, Spain)		 10/07/2018-31/01/2023 Team member
PI18/01030 Rehabilitación cognitiva y plasticidad cerebral en la esclerosis múltiple: en búsqueda de la evidencia. Instituto de Salud Carlos III FIS-ISCIII.
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute), Barcelona, Spain)		 01/01/2019-31/12/2021 Team member
RD16/0015/0002 Redes temáticas de investigación de cooperativa en salud. Red esclerosis múltiple (REEM). IDIBAPS (August Pi i Sunyer Biomedical Research Institute) 01/01/2017-31/12/2021 Team member
PI15/00587 Biomarcadores de resonancia magnética avanzada en esclerosis múltiple: asociación con el perfil clínico evolutivo y el sustrato genético. Instituto de Salud Carlos III (ISCIII).
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute), Barcelona, Spain)		 01/01/2016-30/11/2020 Team member
CEIC 7965 Non-conventional MRI as predictive marker of treatment response. TEVA Spain SLU.
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute))		 01/03/2013-31/12/2018 Team member
RD12/0032/0002 Red Española de Esclerosis Múltiple (REEM) MINISTERIO DE SANIDAD Y CONSUMO.
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute))		 01/01/2013-01/01/2016 Team member
Not Provided Rehabilitación cognitiva y plasticidad cerebral en la Esclerosis Múltiple: evaluación a través de un ensayo clínico aleatorizado y controlado Fundación Merck Salud.
(IDIBAPS (August Pi i Sunyer Biomedical Research Institute), Barcelona, Spain)		 01/06/2017-01/07/2021 Team member

Workshops & Educational series

  1. 2nd National Course of SPM (Statistical Parametric Mapping). September, 2010. Barcelona, Spain.
  2. Annual Meeting of the Organization for Human Brain Mapping. June 26-30, 2011. Québec City, Canada.
  3. ISMRM Workshop on Diffusion as a Probe of Neural Tissue Microstructure. October 14-18, 2013. Podstrana, Croatia.
  4. 31st Congress of the European committee for treatment and research in Multiple Sclerosis (ECTRIMS). October 7-10 , 2015. Barcelona, Spain.
  5. ESMRMB course of clinical fMRI & DTI. June 16-18, 2016. Barcelona, Spain.
  6. School on brain connectomics. October 09-13, 2017. Verona, Italy.
  7. Spinal Cord MRI workshop@UCL. January 21-22, Gower Street, London, United Kingdom.
  8. Annual Meeting of the Organization for Human Brain Mapping. June 09-13, 2019. Roma, Italy.
  9. 36th Annual Scientific Meeting of the ESMRMB. October 3-5, 2019. Rotterdam, Netherlands. Scientific Sessions A-1330. Microscopic diffusion anisotropy imaging as a potential biomarker for the pathogenesis of Multiple Sclerosis lesions.